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Category:2010 softwareRole of heme protein in respiratory burst and killing activity of human neutrophils.
The role of heme protein in respiratory burst and cytotoxic activity of human neutrophils was investigated by stimulation of cells with N-formyl-methionyl-leucyl-phenylalanine (FMLP) in the presence of the iron chelators deferoxamine (DFO) and desferrioxamine (DFO). At a concentration of 250 microM, DFO inhibited the release of superoxide anion by neutrophils stimulated with FMLP, while DFO enhanced the superoxide anion release stimulated with phorbol myristate acetate (PMA). On the contrary, DFO (250 microM) and DFO (1 mM) enhanced the spontaneous and FMLP-stimulated superoxide anion release. In the presence of 250 microM DFO, the cytotoxic activity of neutrophils was reduced, whereas the cytotoxic activity of neutrophils stimulated with FMLP in the presence of 10 mM DFO was augmented. These results suggest that the activation of the respiratory burst in human neutrophils is inhibited by DFO and that the role of the iron chelators in the stimulation of the respiratory burst in human neutrophils is different from that in rat neutrophils.Sexuality in individuals with serious mental illness: the role of serotonergic psychopharmacotherapy.
There is a paucity of research examining sexuality in individuals with serious mental illness (SMI). The serotonin system is a neurobiological substrate that has been implicated in the sexual dysfunction experienced by some individuals with SMI. Sexual dysfunction in individuals with SMI has been linked to neuroleptic medication and this has the potential to affect serotonergic functioning. In the present review, we discuss the role of the serotonin system in the pathogenesis ac619d1d87
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